Second leg matches take place on 5th January except where stated. (18.11.10)
Results were as follows (aet - after extra time, pso - penalty shoot out, teams qualifying in bold): match reports
Draw for first leg and subsequent rounds
| Villarreal Cazorla, Rossi (2, 1 Pen), Marco Rubén |
4-2 | Valencia Banega, Soldado |
| Málaga |
0-3 | Sevilla Romaric, Perotti, Luis Fabiano |
| Levante Xisco Muñoz (Pen), Sergio |
2-0 | Real Madrid |
| Espanyol Luis García |
1-1 | Atlético Madrid
Agüero |
| Mallorca Cavenaghi (2), Pereira |
3-4 | Almería Piatti (2), Juanma Ortíz (2) |
| Deportivo Adrián (3, 2 Pens) |
3-1 (aet) |
Córdoba Arteaga |
| Athletic Bilbao Llorente |
1-1 | Barcelona Abidal |
| Getafe Casquero |
1-3 | Betis Jorge Molina, Rubén Castro (2) |