Second leg matches of the Spanish cup take place on or around 28th November. (18.10.12)
Results were as follows (aet: after extra time, pso: penalty shoot out, teams qualifying in bold): match reports
| Rayo Vallecano |
0-0 | Las Palmas |
| Osasuna Llorente, Rubén |
2-0 | Sporting Gijón |
| Real Sociedad Griezmann, Agirretxe |
2-2 | Córdoba Kiko Olivas, Dubarbier |
| Betis Amaya, Rubén Castro, Rueda (OG) |
3-0 | Valladolid |
| Real Madrid Di María, Callejón (2) |
3-0 | Alcoyano |
| Málaga |
0-1 | Cacereño Chapi |
| Valencia Rami, Valdez, Bernat |
3-1 | Llagostera Nico |
| Atlético Madrid
Raúl García |
1-0 | Real Jaén |
| Levante Nikos, Roger, Michel, Iborra (Pen) |
4-1 | Melilla Chota |
| Getafe |
0-0 | Ponferradina |
| Barcelona Adriano, Villa (2) |
3-1 | Alavés Viguera |
| Espanyol |
0-3 | Sevilla Perotti (Pen), Rakitic, Babá |
| Celta Park Chu-Young, Roberto Lago, De Lucas |
3-0 (aet) |
Almería |
| Granada Ighalo, Mainz |
2-1 | Zaragoza José Marí |
| Mallorca |
0-0 | Deportivo |
| Athletic Bilbao Aduríz |
1-1 | Eibar Arruabarrena (Pen) |