The four regional group champions play off over two legs for two of the promotion spots. First leg ties are as follows:
| 22 May | UCAM Murcia Iván Aguilar (2) |
2-1 | Real Madrid Castilla Febas |
| 22 May | Racing Santander |
0-3 | Reus Vítor, Dínis, Haro |
The remaining twelve teams who finished in the top four of the regional groups enter a knock-out stage, with the winners of the six games entering a second round together with the two losers of the above two ties.
| 22 May | UD Logroñés |
0-0 | Villarreal B |
| 22 May | Toledo |
0-0 | Real Murcia |
| 21 May | Lleida Esportiu Colinas |
1-0 | Barakaldo |
| 21 May | Cádiz |
0-0 | Racing Ferrol |
| 22 May | Tudelano |
0-1 | Hércules Javi Flores |
| 21 May | Sevilla Atlético Carlos Fernández |
1-1 | Socuéllamos Jordi Gómez |
The four sides who finished fifth from bottom in the regional groups have to play-off to avoid the two remaining relegation spots.
| 22 May | Cacereño |
0-0 | Linares |
| 22 May | Olimpic Xativa San Julián |
1-1 | Leioa Bonílla |