Second leg matches of the Spanish cup take place on 21st December except where stated. (14.10.11)
Results were as follows (aet - after extra time, pso - penalty shoot out, teams qualifying in bold): match reports
| Valencia Víctor Ruíz, Jonas, Soldado, Banega |
4-0 | Cádiz |
| Barcelona Pedro (Pen), Iniesta, Thiago (2, 1 Pen), Xavi, Tello (2), Isaac Cuenca (2) |
9-0 | L'Hospitalet |
| Real Madrid Callejón (2), Sahin, Varane, Joselu |
5-1 | Ponferradina Acorán |
| Villarreal |
0-2 | Mirandés Pablo Infante (2) |
| Sevilla Kanouté (2, 1 Pen) |
2-1 | San Roque Adri |
| Atlético Madrid |
0-1 | Albacete Víctor Curto |
| Athletic Bilbao Ander Herrera |
1-0 | Oviedo |
| Osasuna Lamah |
1-1 | Almería Goitom |
| Zaragoza |
0-2 | Alcorcón Oriol Riera, Quini |
| Espanyol Weiss, Alvaro Vázquez, Hugo Mallo (OG), Sergio García |
4-2 | Celta David Rodríguez (2) |
| Betis Jorge Molina (2) |
2-1 | Córdoba Borja |
| Levante El Zhar, Ballesteros, Rubén Suárez, Koné |
4-1 (aet) |
Deportivo Pablo Alvarez (Pen) |
| Sporting Gijón |
0-2 | Mallorca Menéndez (OG), Nsue |
| Rayo Vallecano Torrejón (OG), Michu, Delibasic, Tamudo |
4-3 | Racing Santander Tziolis, Stuani (2, 1 Pen) |
| Málaga Van Nistelrooy, Buonanotte |
2-2 | Getafe Caballero (OG), Mané |
| Granada Siquiero, Geijo |
2-1 | Real Sociedad Agirretxe |