Fifth round second leg fixtures are as set out below. (23.12.11)
Results were as follows (aet - after extra time, pso - penalty shoot out, teams qualifying in bold): match reports
| Espanyol Alvaro Vázquez (3), Didac |
4-2 | Córdoba Alberto, Pepe Díaz |
| Racing Santander Munitis |
1-1 | Mirandés Pablo Infante (Pen) |
| Athletic Bilbao Susaeta, Ander Herrera, Toquero, San José |
4-0 | Albacete |
| Mallorca Chori Castro (2), Hemed (2), Nunes, Alfaro |
6-1 | Real Sociedad Ifrán |
| Sevilla Rakitic, Víctor Ruíz (OG) |
2-1 | Valencia Soldado |
| Levante Barkero, Roger, Iborra, Rubén Suárez |
4-0 | Alcorcón |
| Osasuna Lekic |
1-2 | Barcelona Alexis, Sergi Roberto |
| Málaga |
0-1 | Real Madrid Benzema |